Leading experts engaged in the science-policy interface of public health, biodiversity, and climate change collaborate in an innovative initiative led by the World Health Organization (WHO) and International Union for Conservation of Nature (IUCN) to help guide decision makers toward a healthier, greener and more sustainable future as they navigate the challenges of the post-COVID-19 era. The most recent Pandemic is being handled for the time being and will in all likelihood be overcome in the not so far, future. However, how likely are we to face such dire circumstances soon, what the impact of recurring crises may be and what part have we played in causing this? Finding solutions to common environmental and public health threats requires intensive cross-sectoral and interdisciplinary knowledge exchange. Thus, at the end of the most recent Covid-19 pandemic, the WHO and IUCN are creating an expert working group (EWG) on Biodiversity, Climate, One Health, and Nature-based Solutions. The group’s main purpose will be to develop tools and methods for identifying co-benefits and trade-offs for human and ecosystem health, strengthening social and ecological resilience, and supporting a healthy, green, and just recovery from Covid-19.