At the end of June 2021, the Italian SNPA (National System for Environmental Protection) published its report on climate change indicators (2021 edition), whose main goal is to systematize for the first time both the national and regional climate change impact indicators. The report is a detailed document describing adaptation and mitigation policies from international to regional level, past climate trend and future projections, observed climate change impacts, national indicators and regional pilot cases for a number of impact sectors, as well as national projects focusing on climate change impact. In particular, this last chapter describes both recently ended and ongoing national projects dealing with climate mitigation and adaptation practices and tools, including our LIFE ASTI with specific regard to the urban heat island forecasting and health warning systems.